The amphitheatre was one of the most favourite and attended places by citizens during the Roman age. It was an open-top enclosed building with seats all around the elliptical arena. The seats were wooden and installed in the slope above the arena. On the south side was the main entrance through which the combatants entered. In a special arched niche in front of the entrance was placed the statue of the deity (probably Nemesis), the patron of games in the amphitheatre. On the north side there were three entrances from which animals were released. On both long sides of the ellipse were the premises for the service personnel.

In the Diocletianopolis amphitheatre, various spectacular performances took place – gladiators and animals fights. After Christianity became an official religion in 313, the amphitheatre became a sports venue and stopped functioning as a spectacle venue.